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KMID : 0903520000430010072
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2000 Volume.43 No. 1 p.72 ~ p.77
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Isolation of Anticonvulsant Compounds from the Fruits of Schizandra chinensis BAILI.
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박진규/Park, Jin Kyu
백남인/안은미/최수영/조성우/한재택/김중권/Baek, Nam In/Ahn, Eun Mi/Choi, Soo Young/Cho, Sung Woo/Han, Jae Taek/Kim, Choong Kwon
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Abstract
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The repeated silica gel colum chromatographies of EtOAc fraction, showing anticonvulsant activity, obtained from MeOH extracts of Schizandra chinensis B. fruits led to isolation of a sesquiterpenoid, four lignans and a sterol glycoside. Their chemical structures were determined to be chamigrenal, gomisin A, gomisin H, gomisin N. schizandrin and daucosterol. Among them, schizandrin and daucosterol inhibited GABA degrative enzymes, succinic semialdehyde dehydrogenase and succinic semialdehyde reductase, respectively. It is postulated that the schizandrin and daucosterol are able to elevate the neurotransmitter GABA levels in central nervous system by inhibitory action on GABA degrative enzymes and act as anticonvulsant drugs.
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